| Primary Identifier | IPR030118 | Type | Family |
| Short Name | FLT3 |
| description | FLT3 is a class III receptor tyrosine kinase that plays an important role in hematopoietic differentiation. Mutations in FLT3 that lead to constitutive activation are among the most common molecular lesions found in acute myeloid leukemia (AML) [, ]. FLT3 can be regulated by protein-tyrosine phosphatase DEP-1 []. An adaptor protein, Grb10, has been shown to bind both normal and oncogenic FLT3 and induces PI3K-Akt and STAT5 signalling pathways resulting in an enhanced proliferation, survival and colony formation of hematopoietic cells []. |
