| Primary Identifier | MGI:1855961 | Allele Type | Spontaneous |
| Gene | Tyrp1 | Inheritance Mode | Recessive |
| Strain of Origin | (DBA/1 x C57BL/10)F1 | Is Recombinase | false |
| Is Wild Type | false |
| description | Homozygous recessive mutant on a nonagouti/black background are chocolate brown and show altered melanin granule morphology. Semidominant mutants result in melanocyte degeneration causing reduced pigmentation and progressive hearing loss. |
| molecularNote | Complementation testing demonstrated that this mutation is an allele of the original brown (Tyrp1b) mutation. The Tyrp1b-c allele was found among (DBA/1 X C57BL/10)F1 offspring. Because DBA is homozygous for Tyrp1b, the mutation occurred on C57BL10. |
