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Protein Coding Gene : Unc80 unc-80, NALCN activator
Primary Identifier  MGI:2652882 Organism  mouse, laboratory
Chromosome  1 NCBI Gene Number  329178
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable monoatomic cation channel activity. Predicted to be involved in monoatomic cation homeostasis. Part of sodium channel complex. Orthologous to human UNC80 (unc-80 homolog, NALCN channel complex subunit).
PHENOTYPE: Mice homozygous for a null allele die within 24 hours of birth, exhibit severe apnea and hippocampal neurons show decreased NALCN-dependent sodium leak current. [provided by MGI curators]
  • synonyms:
  • Unc80,
  • RIKEN cDNA C230061B10 gene,
  • MGI:2445028,
  • RIKEN cDNA C030018G13 gene,
  • BC042720,
  • C030018G13Rik,
  • C230061B10Rik,
  • unc-80, NALCN activator,
  • cDNA sequence BC042720,
  • MGI:1925858
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Features --> Cross References

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2 Involved In Mutations

Trail: ProteinCodingGene

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

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Homology

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3 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

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Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

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