| First Author | Tamura T | Year | 1991 |
| Journal | Nucleic Acids Res | Volume | 19 |
| Issue | 14 | Pages | 3861-5 |
| PubMed ID | 1861978 | Mgi Jnum | J:21431 |
| Mgi Id | MGI:69409 | Doi | 10.1093/nar/19.14.3861 |
| Citation | Tamura T, et al. (1991) Striking homology of the 'variable' N-terminal as well as the 'conserved core' domains of the mouse and human TATA-factors (TFIID). Nucleic Acids Res 19(14):3861-5 |
| abstractText | A complementary DNA (cDNA) encoding a mouse TFIID (mIID) was isolated from mouse brain cDNA libraries. The 316 amino acid sequence deduced from cDNA sequences revealed the presence of an amino-terminal region enriched in serine, threonine, and proline (STP-cluster), an uninterrupted stretch of 13 glutamine residues (Q-run), a second STP-cluster, and a conserved carboxy-terminal region. Amino acid sequences of the first STP-cluster and the conserved carboxy-terminal region were identical to those of the human TFIID (hIID). However, the Q-run was considerably shorter than that in hIID and sequences in the second STP-cluster diverged from those of the hIID. The murine TFIID transcript is expressed as a 2 kilobase poly(A)+ RNA in the mouse brain. Southern blot analysis identified a single gene copy per haploid mouse genome. |
