Primary Identifier | MGI:1098658 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 20842 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables chromatin binding activity. Predicted to be involved in localization; mitotic spindle assembly; and sister chromatid cohesion. Predicted to act upstream of or within cell division and chromosome segregation. Part of chromatin. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and respiratory system. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 47. Orthologous to human STAG1 (STAG1 cohesin complex component). PHENOTYPE: Mouse embryos homozygous for a null mutation show developmental delay and die before birth. Heterozygous animals have shorter lifespan and earlier onset of tumourigenesis. [provided by MGI curators] |