| Primary Identifier | MGI:1276578 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 14582 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in positive regulation of granulocyte differentiation and regulation of erythrocyte differentiation. Predicted to be located in nuclear matrix; nucleoplasm; and plasma membrane. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in eye; gut; hemolymphoid system; liver; and testis. Human ortholog(s) of this gene implicated in gray platelet syndrome and platelet-type bleeding disorder 17. Orthologous to human GFI1B (growth factor independent 1B transcriptional repressor). PHENOTYPE: Mice homozygous for disruption of this gene die as embryos by day E15. Mature adult red blood cells and megakaryocytes fail to develop. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
