| Primary Identifier | MGI:1346859 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 26417 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables MAP kinase activity and phosphotyrosine residue binding activity. Involved in several processes, including MAPK cascade; nervous system development; and transmembrane receptor protein tyrosine kinase signaling pathway. Acts upstream of or within several processes, including Bergmann glial cell differentiation; ERK1 and ERK2 cascade; and respiratory system development. Located in cytosol; nucleus; and pseudopodium. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in colon adenocarcinoma; colorectal adenocarcinoma; endometrial adenocarcinoma; pancreatic ductal carcinoma; and pulmonary hypertension. Orthologous to human MAPK3 (mitogen-activated protein kinase 3). PHENOTYPE: Mice homozygous for a targeted null mutation are hyperactive with impaired T cell maturation and proliferation. Mice homozygous for a knock-out allele on a CD-1 background exhibit normal Mendelian ratios, growth, and no obvious abnormalities. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
