| First Author | Yuan M | Year | 2005 |
| Journal | FEBS Lett | Volume | 579 |
| Issue | 11 | Pages | 2339-47 |
| PubMed ID | 15848169 | Mgi Jnum | J:98236 |
| Mgi Id | MGI:3577682 | Doi | 10.1016/j.febslet.2005.03.031 |
| Citation | Yuan M, et al. (2005) Fyn binding protein, Fyb, interacts with mammalian actin binding protein, mAbp1. FEBS Lett 579(11):2339-47 |
| abstractText | The immune cell specific protein Fyn-T binding protein (Fyb) has been identified as a target of the Yersinia antiphagocytic effector Yersinia outer protein H (YopH), but its role in macrophages is unknown. By using Fyb domains as bait to screen a mouse lymphoma cDNA library, we identified a novel interaction partner, mammalian actin binding protein 1 (mAbp1). We show that mAbp1 binds the Fyb N-terminal via its C-terminally located src homology 3 domain. The interaction between Fyb and mAbp1 is detected in macrophage lysates and the proteins co-localize with F-actin in the leading edge. Hence, mAbp1 is likely to constitute a downstream effector of Fyb involved in F-actin dynamics. |
