| Primary Identifier | MGI:102765 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 19275 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable GTPase binding activity; spectrin binding activity; and ubiquitin-like protein ligase binding activity. Involved in insulin secretion involved in cellular response to glucose stimulus; luteinization; and positive regulation of type B pancreatic cell proliferation. Predicted to be located in axon terminus; neuronal cell body; and nucleus. Predicted to be active in secretory granule and synapse. Predicted to colocalize with Golgi apparatus; endosome; and plasma membrane. Is expressed in lens vesicle and nervous system. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human PTPRN (protein tyrosine phosphatase receptor type N). PHENOTYPE: Mice homozygous for a disruption in this gene on a NOD background display insulitis and increased susceptibility to autoimmune diabetes. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
