| Primary Identifier | IPR024101 | Type | Family |
| Short Name | TFEC |
| description | The MiT/TFE family of basic helix-loop-helix leucine zipper transcription factors includes MITF (microphthalmia-associated transcription factor) and related family members TFE3, TFEB and TFEC []. The transcription factors heterodimerize with each other and recognise the same DNA sequences []. They recognise and bind E-box sequences (3'-CANNTG-5').This entry represents transcription factor EC (TFEC). TFEC can act as a repressor or an activator. It acts as a transcriptional repressor on minimal promoter containing muE3 enhancer sequence []and as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter []. It binds DNA in a homo or heterodimeric form with MITF and TFE3. |
