| Primary Identifier | MGI:101910 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 14063 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables G-protein alpha-subunit binding activity; G-protein beta-subunit binding activity; and proteinase-activated receptor activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of intracellular signal transduction; and regulation of protein secretion. Acts upstream of or within G protein-coupled receptor signaling pathway. Located in pseudopodium. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and skin. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and respiratory allergy. Orthologous to human F2RL1 (F2R like trypsin receptor 1). PHENOTYPE: Nullizygous mice may exhibit impaired leukocyte rolling and dendritic cell maturation, altered inflammatory response in various models of acute and chronic inflammatory disease, altered susceptibility to injury and to autoimmune disorders, and abnormal hemodynamic responses and pain thresholds. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
