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Publication : The mammalian homologues of frog Bv8 are mainly expressed in spermatocytes.

First Author  Wechselberger C Year  1999
Journal  FEBS Lett Volume  462
Issue  1-2 Pages  177-81
PubMed ID  10580115 Mgi Jnum  J:58759
Mgi Id  MGI:1349649 Doi  10.1016/s0014-5793(99)01473-8
Citation  Wechselberger C, et al. (1999) The mammalian homologues of frog Bv8 are mainly expressed in spermatocytes. FEBS Lett 462(1-2):177-81
abstractText  Bv8, a protein from skin secretions of Bombina variegata, reacts with receptors present in mammalian brain and intestine (Mollay et al. (1999) Eur. J. Pharmacol. 374, 189-196). As deduced from cloned cDNAs, the murine and human Bv8 homologues have identical amino-terminal sequences and also contain 10 cysteines. From mouse testes, two forms of Bv8 mRNA have been characterized, of which one contains an additional exon which codes for 21 mostly basic amino acids. The mouse Bv8 gene is most active in mid-late pachytene spermatocytes. In mouse testes, Bv8 mRNA can first be detected at the end of the second week post partum.
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