| First Author | Chee J | Year | 2014 |
| Journal | J Immunol | Volume | 192 |
| Issue | 2 | Pages | 572-80 |
| PubMed ID | 24337380 | Mgi Jnum | J:207331 |
| Mgi Id | MGI:5556014 | Doi | 10.4049/jimmunol.1302100 |
| Citation | Chee J, et al. (2014) Effector-memory T cells develop in islets and report islet pathology in type 1 diabetes. J Immunol 192(2):572-80 |
| abstractText | CD8(+) T cells are critical in human type 1 diabetes and in the NOD mouse. In this study, we elucidated the natural history of islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP)-specific CD8(+) T cells in NOD diabetes using MHC-tetramer technology. IGRP206-214-specific T cells in the peripheral lymphoid tissue increased with age, and their numbers correlated with insulitis progression. IGRP206-214-specific T cells in the peripheral lymphoid tissue expressed markers of chronic Ag stimulation, and their numbers were stable after diagnosis of diabetes, consistent with their memory phenotype. IGRP206-214-specific T cells in NOD mice expand, acquire the phenotype of effector-memory T cells in the islets, and emigrate to the peripheral lymphoid tissue. Our observations suggest that enumeration of effector-memory T cells of multiple autoantigen specificities in the periphery of type 1 diabetic subjects could be a reliable reporter for progression of islet pathology. |
