| Primary Identifier | IPR032022 | Type | Domain |
| Short Name | NUDIX |
| description | This domain is found in higher eukaryotes at the N terminus of KRIT1 or Krev interaction trapped proteins. KRIT1 is a 736 amino acid protein that contains three regions, an N-terminal NPxY motif-rich region, an ankyrin repeat domain (ARD) and a band four-point-one, ezrin, radixin, moesin (FERM) domain. The N-terminal region of KRIT1 contains three NPxY-like motifs and can bind ICAP1 (integrin cytoplasmic-associated protein 1 (ICAP1). In the absence of KRIT1, ICAP1 binds via its C-terminal PH/PTB fold domain to the integrin beta-1 cytoplasmic tail. Binding of KRIT1 to ICAP1 via this domain out-competes the binding of ICAP1 to integrin cytoplasmic tails such that ICAP1 is sequestered in the nucleus. Integrin activation is thus prevented. KRIT1 does not include the canonical "Nudix box"motif or other Nudix motifs but does, however, very clearly adopt a Nudix fold with a central β-sheet flanked by two α-helices []. |
