| First Author | Wooley PH | Year | 1981 |
| Journal | J Exp Med | Volume | 154 |
| Issue | 3 | Pages | 688-700 |
| PubMed ID | 6792316 | Mgi Jnum | J:40550 |
| Mgi Id | MGI:707881 | Doi | 10.1084/jem.154.3.688 |
| Citation | Wooley PH, et al. (1981) Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates. J Exp Med 154(3):688-700 |
| abstractText | A model of arthritis was established by the injection of type II collagen into mice. Only mice bearing the H-2q haplotype were susceptible to the disease. Susceptibility was further mapped by the use of recombinant strains on the Iq locus. Type II collagen arthritis was observed in the (resistant X susceptible) F1 cross. Mice strains were designated high, intermediate, or low responders with respect to the anti-type II antibody levels measured by radioimmunoassay. Arthritis-susceptible strains were all classified as high antibody responders. The clinical and histological appearance of type II collagen arthritis in the mouse indicates that it may be a good animal model for the investigation of various immunogenetic traits in rheumatoid arthritis. |
