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Allele : Esr1<tm1.1Elev> estrogen receptor 1 (alpha); targeted mutation 1.1, Ellis R Levin
Primary Identifier  MGI:6759468 Allele Type  Targeted
Gene  Esr1 Transmission  Germline
Strain of Origin  129P2/OlaHsd Is Recombinase  false
Is Wild Type  false
molecularNote  A cysteine to alanine mutation at residue 451 (C451A) and a neomycin selection cassette flanked by FRT sites were inserted into the locus. Flp-mediated recombination removed the neomycin cassette. This mutation abolishes palmitoylation and membrane trafficking of the receptor.
  • mutations:
  • Nucleotide substitutions
  • synonyms:
  • NOER KI,
  • NOER KI
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

6 Publication categories

Trail: Allele




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