| First Author | Kitaguchi T | Year | 1998 |
| Journal | Blood Coagul Fibrinolysis | Volume | 9 |
| Issue | 4 | Pages | 381-5 |
| PubMed ID | 9690810 | Mgi Jnum | J:51437 |
| Mgi Id | MGI:1316621 | Doi | 10.1097/00001721-199806000-00011 |
| Citation | Kitaguchi T, et al. (1998) Characterization of cDNA encoding full-length mouse platelet glycoprotein IX. Blood Coagul Fibrinolysis 9(4):381-5 |
| abstractText | Glycoprotein (GP) IX is a platelet membrane 20 kD protein, which is associated with GPIbalpha, GPIb beta, and GPV to form GPIb/IX/V complex. GPIb/IX/V complex is a major receptor for von Willebrand factor, which mediates platelet adhesion and aggregation under high shear stress conditions. The relevance of this receptor for hemostasis has been implicated by a congenital bleeding disorder lacking the receptor, Bernard-Soulier syndrome. All subunits for the human receptor have been cloned and characterized. However, the function of GPIX is still elusive. To obtain further information of GPIX, we have determined a cDNA sequence of mouse GPIX (811 bp). The deduced amino-acid sequence (177aa) was 71% identical to the human GPIX protein. All cysteine residues in extracytoplasmic domain and putative N-linked glycosylation site (Asn44) were conserved. Mouse GPIX contained a leucine-rich glycoprotein sequence composed of 24 amino acids, as did human GPIX. |
