Primary Identifier | MGI:3832877 | Allele Type | Transgenic |
Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(Thy1-MAPT*V337M)1Godt |
Strain of Origin | (C57BL/6J x CBA/Ca)F1 | Is Recombinase | false |
Is Wild Type | false |
molecularNote | The promoter was used to drive brain-specific expression of a cDNA that encodes the longest three-repeat human isoform with nucleotide substitutions resulting in the amino acid substitution of methionine for valine at position 337 (V337M). This mutation was originally identified in patients with frontotemporal dementias with Parkinsonism linked to chromosome 17 (FTDP-17). No line information was given. |