| First Author | Jacobs BB | Year | 1978 |
| Journal | J Natl Cancer Inst | Volume | 61 |
| Issue | 6 | Pages | 1531-4 |
| PubMed ID | 281561 | Mgi Jnum | J:70434 |
| Mgi Id | MGI:2137222 | Citation | Jacobs BB, et al. (1978) Spontaneous hepatomas in mice inbred from Ha:ICR Swiss stock: effects of sex, cedar shavings in bedding, and immunization with fetal liver or hepatoma cells. J Natl Cancer Inst 61(6):1531-4 |
| abstractText | Mice from Ha:ICR noninbred Swiss stock were mated brother X sister for 21--25 generations and then maintained up to the age of 33 months. Hepatomas developed in 62.8% of 86 males autopsied at 349--999 days of age (mean age = 21.1 mo). Of 130 females, 6.9% had hepatomas when autopsied at 328-825 days of age (mean age = 18.7 mo). Hepatoma incidence in males at 18 months of age was not affected by the presence or absence of cedar shavings in the bedding or by immunization of 3-month-old males with 2 weekly inoculations of 150 microgram (protein) sonicate of fetal liver or spontaneous hepatoma cells. |
