| First Author | Zou Q | Year | 2015 |
| Journal | Cell Rep | Volume | 13 |
| Issue | 11 | Pages | 2470-2479 |
| PubMed ID | 26686633 | Mgi Jnum | J:272219 |
| Mgi Id | MGI:6274184 | Doi | 10.1016/j.celrep.2015.11.046 |
| Citation | Zou Q, et al. (2015) T Cell Intrinsic USP15 Deficiency Promotes Excessive IFN-gamma Production and an Immunosuppressive Tumor Microenvironment in MCA-Induced Fibrosarcoma. Cell Rep 13(11):2470-2479 |
| abstractText | USP15 is a deubiquitinase that negatively regulates activation of naive CD4(+) T cells and generation of IFN-gamma-producing T helper 1 (Th1) cells. USP15 deficiency in mice promotes antitumor T cell responses in a transplantable cancer model; however, it has remained unclear how deregulated T cell activation impacts primary tumor development during the prolonged interplay between tumors and the immune system. Here, we find that the USP15-deficient mice are hypersensitive to methylcholantrene (MCA)-induced fibrosarcomas. Excessive IFN-gamma production in USP15-deficient mice promotes expression of the immunosuppressive molecule PD-L1 and the chemokine CXCL12, causing accumulation of T-bet(+) regulatory T cells and CD11b(+)Gr-1(+) myeloid-derived suppressor cells at tumor site. Mixed bone marrow adoptive transfer studies further reveals a T cell-intrinsic role for USP15 in regulating IFN-gamma production and tumor development. These findings suggest that T cell intrinsic USP15 deficiency causes excessive production of IFN-gamma, which promotes an immunosuppressive tumor microenvironment during MCA-induced primary tumorigenesis. |
