| First Author | Decressac S | Year | 2004 |
| Journal | EMBO Rep | Volume | 5 |
| Issue | 12 | Pages | 1171-5 |
| PubMed ID | 15540117 | Mgi Jnum | J:95306 |
| Mgi Id | MGI:3525805 | Doi | 10.1038/sj.embor.7400292 |
| Citation | Decressac S, et al. (2004) ARF6-dependent interaction of the TWIK1 K+ channel with EFA6, a GDP/GTP exchange factor for ARF6. EMBO Rep 5(12):1171-5 |
| abstractText | TWIK1 belongs to a family of K(+) channels involved in neuronal excitability and cell volume regulation. Its tissue distribution suggests a role in epithelial potassium transport. Here we show that TWIK1 is expressed in a subapical compartment in renal proximal tubules and in polarized MDCK cells. In nonpolarized cells, this compartment corresponds to pericentriolar recycling endosomes. We identified EFA6, an exchange factor for the small G protein ADP-ribosylation factor 6 (ARF6), as a protein binding to TWIK1. EFA6 interacts with TWIK1 only when it is bound to ARF6. Because ARF6 modulates endocytosis at the apical surface of epithelial cells, the ARF6/EFA6/TWIK1 association is probably important for channel internalization and recycling. |
