| Primary Identifier | MGI:2156926 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Dsc1 |
| Transmission | Germline | Strain of Origin | Not Specified |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A PGK-neomycin resistance cassette replaced 2.2kb of intron 1 and 98bp of exon 1, including the translation initiation codon and sequences encoding the start of the signal peptide. RT-PCR analysis did not detect message in epidermis from 2 day old homozygous mutant mice. Western blot analysis using a polyclonal antibody raised against a substantial portion of the extra cellular domain did not detect protein in epidermis from 2 day old homozygous mutant mice. Immunofluorescence studies did not detect protein in epidermis and inner root sheaths of hair follicles from 2 day old mice homozygous mutant mice. |
