| Primary Identifier | IPR035038 | Type | Family |
| Short Name | TRIM72 |
| description | TRIM72, also known as MG53, is a cardiac and skeletal muscle-specific TRIM protein. It is involved in cardiac and skeletal muscle membrane repair []. TRIM72 initiates the assembly of cell membrane repair machinery at sarcolemmal membrane injury sites in response to entry of the extracellular oxidative environment []. As an E3 ligase, it negatively regulates skeletal myogenesis and insulin signalling by targeting insulin receptor substrate 1 (IRS-1) [].Tripartite Motif (TRIM) family members share a common domain architecture characterised by the presence of a modular N-terminal RBCC motif, also called the TRIM, which consists of a RING domain, followed by one or two B-box domains and a long coiled coil (CC) region. The RBCC motif is followed by C-terminal functional domains that are often used to categorise family members into subgroups [].TRIM72 C terminus consists of the distinct N-terminal PRY subdomain followed by the SPRY subdomain. |
