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Publication : Siglec-G is a B1 cell-inhibitory receptor that controls expansion and calcium signaling of the B1 cell population.

First Author  Hoffmann A Year  2007
Journal  Nat Immunol Volume  8
Issue  7 Pages  695-704
PubMed ID  17572677 Mgi Jnum  J:123353
Mgi Id  MGI:3718146 Doi  10.1038/ni1480
Citation  Hoffmann A, et al. (2007) Siglec-G is a B1 cell-inhibitory receptor that controls expansion and calcium signaling of the B1 cell population. Nat Immunol 8(7):695-704
abstractText  B1 cells are an important cell population for the production of natural antibodies and for antibacterial immunoglobulin responses. Here we identified the mouse protein Siglec-G as a B1 cell inhibitory receptor. Siglec-G was expressed in a B cell-restricted way, with large amounts present in B1 cells. When overexpressed, Siglec-G inhibited B cell receptor-mediated calcium signaling. Siglec-G-deficient mice had massive expansion of the B1a cell population, which began early in development and was B cell intrinsic. Siglec-G-deficient mice had higher titers of natural IgM antibodies but not a higher penetrance of IgG autoantibodies. Siglec-G-deficient B1 cells showed a strongly enhanced calcium signaling. Our results demonstrate that Siglec-G-dependent negative regulation exists in B1 cells, which may explain the naturally muted signaling response of B1 cells.
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