| First Author | Vasey DB | Year | 2008 |
| Journal | Toxicol Appl Pharmacol | Volume | 227 |
| Issue | 3 | Pages | 440-50 |
| PubMed ID | 18215733 | Mgi Jnum | J:150334 |
| Mgi Id | MGI:3850423 | Doi | 10.1016/j.taap.2007.11.029 |
| Citation | Vasey DB, et al. (2008) p21-LacZ reporter mice reflect p53-dependent toxic insult. Toxicol Appl Pharmacol 227(3):440-50 |
| abstractText | There is an urgent need to discover less toxic and more selective drugs to treat disease. The use of transgenic mice that report on toxic insult-induced transcription can provide a valuable tool in this regard. To exemplify this strategy, we have generated transgenic mice carrying a p21-LacZ transgene. Transgene activity reflected endogenous p21 gene activation in various tissues, displayed compound-specific spatial expression signatures in the brain and immune tissues and enabled p53-dependent and p53-independent responses to be identified. We discuss the application of these mice in delineating the molecular events in normal cellular growth and disease and for the evaluation of drug toxicity. |
