Primary Identifier | MGI:3622094 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Nlrp3 |
Transmission | Germline | Strain of Origin | C57BL/6NTac |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Exons 1-3 were replaced with a neomycin resistance cassette. Exon 3 contains the ATG and the entire pyrin domain; exons 1 and 2 encode the 5' UTR. RT-PCR failed to detect transcript in mutants. |