| First Author | Kitajima T | Year | 1992 |
| Journal | Clin Immunol Immunopathol | Volume | 62 |
| Issue | 1 Pt 1 | Pages | 119-23 |
| PubMed ID | 1728975 | Mgi Jnum | J:1865 |
| Mgi Id | MGI:50389 | Doi | 10.1016/0090-1229(92)90031-i |
| Citation | Kitajima T, et al. (1992) Histological detection of c-myb and c-myc proto-oncogene expression in infiltrating cells in cutaneous lupus erythematosus-like lesions of MRL/l mice by in situ hybridization. Clin Immunol Immunopathol 62(1 Pt 1):119-23 |
| abstractText | A relationship between lymphocytic activation and the overexpression of proto-oncogenes such as c-myb or c-myc has been demonstrated in human autoimmune disease. In autoimmune-prone MRL/l mice, which spontaneously develop lupus erythematosus (LE)-like lesions on the back, increased expression of myb RNA has been found in the lymphoid organs. We detected the overexpression of c-myb and c-myc proto-oncogenes in infiltrating cells in the cutaneous lesions of MRL/l mice by using in situ hybridization. No specific hybridization signals of either of the probes used were seen in the nonlesional skin of MRL/l mice or in the apparently normal skin of aged MRL/n and young MRL/l mice. These results suggest that the increased expression of myb and myc proto-oncogenes in the cutaneous LE-like lesions of MRL/l mice is related to a state of activation in the infiltrating cells and is involved in the development of these lesions. |
