Primary Identifier | IPR040141 | Type | Family |
Short Name | ZPR1 |
description | This family consist of zinc finger protein ZPR1 and ZPR1-like proteins. The function of ZPR1 is not clear. ZPR1 is present in both the cytoplasm and nucleoplasma and its subcellular distribution changes during proliferation []. ZPR1 binds to the cytoplasmic tyrosine kinase domain of the epidermal growth factor receptor (EGFR) []and is a component of downstream signaling of both EGFR and FGFR signaling []. It has been associated with susceptibility to type 2 diabetes []and is downregulated in patients with spinal muscular atrophy []. |