| First Author | Hasegawa E | Year | 2022 |
| Journal | Science | Volume | 375 |
| Issue | 6584 | Pages | 994-1000 |
| PubMed ID | 35239361 | Mgi Jnum | J:323824 |
| Mgi Id | MGI:7256789 | Doi | 10.1126/science.abl6618 |
| Citation | Hasegawa E, et al. (2022) Rapid eye movement sleep is initiated by basolateral amygdala dopamine signaling in mice. Science 375(6584):994-1000 |
| abstractText | The sleep cycle is characterized by alternating non-rapid eye movement (NREM) and rapid eye movement (REM) sleeps. The mechanisms by which this cycle is generated are incompletely understood. We found that a transient increase of dopamine (DA) in the basolateral amygdala (BLA) during NREM sleep terminates NREM sleep and initiates REM sleep. DA acts on dopamine receptor D2 (Drd2)-expressing neurons in the BLA to induce the NREM-to-REM transition. This mechanism also plays a role in cataplectic attacks-a pathological intrusion of REM sleep into wakefulness-in narcoleptics. These results show a critical role of DA signaling in the BLA in initiating REM sleep and provide a neuronal basis for sleep cycle generation. |
