| Primary Identifier | IPR030369 | Type | Family |
| Short Name | ABCA7 |
| description | ATP-binding cassette subfamily A member 7 (ABCA7) belongs to the ABC transporter family, whose remembers are full-length transporters organised in two tandem halves, each with a hydrophobic TMD followed by a cytoplasmic NBD [].In macrophages, ABCA7 functions in phagocytosis and can be stabilised by HDL (high-density lipoprotein) apolipoproteins []. ABCA7 has been linked to Alzheimer's disease pathogenesis [, ]. It is also linked to Sjogrens syndrome, a chronic autoimmune disease characterised by the sicca symptoms of dry eyes and dry mouth [, ]. |
