| First Author | Song Y | Year | 2019 |
| Journal | Cell Metab | Volume | 30 |
| Issue | 5 | Pages | 976-986.e3 |
| PubMed ID | 31495689 | Mgi Jnum | J:281555 |
| Mgi Id | MGI:6376940 | Doi | 10.1016/j.cmet.2019.08.009 |
| Citation | Song Y, et al. (2019) Gut-Proglucagon-Derived Peptides Are Essential for Regulating Glucose Homeostasis in Mice. Cell Metab 30(5):976-986.e3 |
| abstractText | The importance of pancreatic versus intestinal-derived GLP-1 for glucose homeostasis is controversial. We detected active GLP-1 in the mouse and human pancreas, albeit at extremely low levels relative to glucagon. Accordingly, to elucidate the metabolic importance of intestinal proglucagon-derived peptides (PGDPs), we generated mice with reduction of Gcg expression within the distal (Gcg(DistalGut-/-)) or entire (Gcg(Gut-/-)) gut. Substantial reduction of gut Gcg expression markedly reduced circulating levels of GLP-1, and impaired glucose homeostasis, associated with increased levels of GIP, and accelerated gastric emptying. Gcg(DistalGut-/-) mice similarly exhibited lower circulating GLP-1 and impaired oral glucose tolerance. Nevertheless, plasma levels of insulin remained normal following glucose administration in the absence of gut-derived GLP-1. Collectively, our findings identify the essential importance of gut-derived PGDPs for maintaining levels of circulating GLP-1, control of gastric emptying, and glucose homeostasis. |
