| First Author | Paik DH | Year | 2021 |
| Journal | J Exp Med | Volume | 218 |
| Issue | 1 | PubMed ID | 33005934 |
| Mgi Jnum | J:307775 | Mgi Id | MGI:6509789 |
| Doi | 10.1084/jem.20200218 | Citation | Paik DH, et al. (2021) Influenza infection fortifies local lymph nodes to promote lung-resident heterosubtypic immunity. J Exp Med 218(1) |
| abstractText | Influenza infection generates tissue-resident memory T cells (TRMs) that are maintained in the lung and can mediate protective immunity to heterologous influenza strains, but the precise mechanisms of local T cell-mediated protection are not well understood. In a murine heterosubtypic influenza challenge model, we demonstrate that protective lung T cell responses derive from both in situ activation of TRMs and the enhanced generation of effector T cells from the local lung draining mediastinal lymph nodes (medLNs). Primary infection fortified the medLNs with an increased number of conventional dendritic cells (cDCs) that mediate enhanced priming of T cells, including those specific for newly encountered epitopes; cDC depletion during the recall response diminished medLN T cell generation and heterosubtypic immunity. Our study shows that during a protective recall response, cDCs in a fortified LN environment enhance the breadth, generation, and tissue migration of effector T cells to augment lung TRM responses. |
