| First Author | Iwamura C | Year | 2007 |
| Journal | Int Immunol | Volume | 19 |
| Issue | 6 | Pages | 755-62 |
| PubMed ID | 17493960 | Mgi Jnum | J:122295 |
| Mgi Id | MGI:3713967 | Doi | 10.1093/intimm/dxm042 |
| Citation | Iwamura C, et al. (2007) Schnurri-2 regulates Th2-dependent airway inflammation and airway hyperresponsiveness. Int Immunol 19(6):755-62 |
| abstractText | Schnurri (Shn)-2 is a large zinc finger-containing protein, which plays a critical role in cell growth, signal transduction and lymphocyte development. In Shn-2-deficient (Shn-2(-/-)) CD4 T cells, the activation of nuclear factor-kappaB is up-regulated and their ability to differentiate into T(h)2 is enhanced. Here, we extend our investigation and demonstrate that Shn-2 regulates T(h)2 responses in vivo using an ovalbumin-induced allergic asthma model. Eosinophilic inflammation, mucus hyperproduction and airway hyperresponsiveness (AHR) were all enhanced in Shn-2(-/-) mice. Moreover, eosinophilic infiltration and AHR were enhanced in mice given a transfer of Shn-2(-/-) effector T(h)2. Shn-2 in T(h)2 is thus considered to play an important role as a negative regulator in allergic airway inflammation. |
