| First Author | Bulle F | Year | 1987 |
| Journal | Hum Genet | Volume | 76 |
| Issue | 3 | Pages | 283-6 |
| PubMed ID | 2885259 | Mgi Jnum | J:8751 |
| Mgi Id | MGI:57216 | Doi | 10.1007/BF00283624 |
| Citation | Bulle F, et al. (1987) Assignment of the human gamma-glutamyl transferase gene to the long arm of chromosome 22. Hum Genet 76(3):283-6 |
| abstractText | We have determined the chromosomal location of the human gene for gamma-glutamyltransferase (GGT). This study was done by in situ hybridization of human metaphase spreads with a rat cDNA probe specific for this enzyme and constructed from two clones previously characterized in our laboratory. The final construct had a 1.6-kb-long insert covering 92% of the coding sequence for GGT. The new insert was also freed of any GC tails introduced for the cDNA cloning, because we observed that these sequences were responsible for a high background. Using this probe for the analysis of 136 human metaphase spreads, we observed a strong specific signal on chromosome 22 at the interface of q111-112 and a minor peak in q131. Thus GGT might represent a new marker for the study of certain diseases which have chromosomal abnormalities at these loci. |
