| First Author | Huttner KM | Year | 1997 |
| Journal | FEBS Lett | Volume | 413 |
| Issue | 1 | Pages | 45-9 |
| PubMed ID | 9287114 | Mgi Jnum | J:40251 |
| Mgi Id | MGI:1095796 | Doi | 10.1016/s0014-5793(97)00875-2 |
| Citation | Huttner KM, et al. (1997) The mouse genome encodes a single homolog of the antimicrobial peptide human beta-defensin 1. FEBS Lett 413(1):45-9 |
| abstractText | The cysteine-rich beta-defensin peptides are broad- spectrum bactericidal agents expressed in epithelial and myeloid tissues, The human beta-defensin-1 (hBD-1) gene maps adjacent to the human alpha-defensin cluster and is expressed in the respiratory, gastrointestinal and genitourinary tracts, Here, we characterize a mouse beta- defensin gene (mBD-1) which is: (1) closely related to hBD- 1 both in sequence and gene organization; (2) expressed at high levels in the mouse kidney and at lower levels in brain, heart, lung, uterus, spleen, skeletal muscle, stomach, and small intestine; and (3) maps to mouse chromosome 8 at or near the location of the mouse alpha- defensin genes, These data indicate that mBD-1 is a close homolog of hBD-1, and suggest that analysis of its role in mouse host defense may provide significant insights into human epithelial innate immunity, (C) 1997 Federation of European Biochemical Societies. |
