| First Author | Puverel S | Year | 2009 |
| Journal | J Comp Neurol | Volume | 512 |
| Issue | 2 | Pages | 232-42 |
| PubMed ID | 19003791 | Mgi Jnum | J:252601 |
| Mgi Id | MGI:6107642 | Doi | 10.1002/cne.21888 |
| Citation | Puverel S, et al. (2009) Prokineticin receptor 2 expression identifies migrating neuroblasts and their subventricular zone transient-amplifying progenitors in adult mice. J Comp Neurol 512(2):232-42 |
| abstractText | The adult subventricular zone (SVZ) contains progenitors cells, which continually give rise to new neurons that migrate along the rostral migratory stream (RMS) to the olfactory bulbs (OB). Prokineticin receptor 2 (ProKR2) is a G-protein-coupled receptor that plays an essential role in this migration process. However, the identity of the prokr2-expressing cells has not yet been clearly established. Here, we have characterized in detail the identity of the prokr2-expressing cells in the SVZ/RMS/OB pathway in adult mice. In the SVZ, accumulation of prokr2 transcripts was detected in almost all migrating neuroblasts or type A cells as well as in a large population of their precursors, the rapidly dividing type C cells. Moreover, we observed that, in dissociated SVZ cells from Mash1::GFP postnatal mice, ProKR2 protein is also present in type C and type A cells. We found that, along the RMS and in the OB, prokr2 expression was restricted to migrating type A cells and was absent in astrocytes. Finally, we observed a highly marked decrease of prokr2 expression in Mash1-/- mutant mice, suggesting that this transcription factor directly or indirectly regulates prokr2 expression. Although the expression of ProKR2 in migrating type A cells is in good agreement with the essential role played by this receptor during this migration process, its expression in a large population of their progenitors suggests an additional function for ProKR2, providing novel insights into the role of ProKR2/ProK2 signalling in adult neurogenesis. |
