| Primary Identifier | IPR027523 | Type | Family |
| Short Name | CLU_prot |
| description | This entry includes protein clueless from Drosophila, Clu1 from yeasts and protein CLU from plants. They are involved in proper cytoplasmic distribution of mitochondria [, ].Protein clueless from Drosophila is required for mitochondrial subcellular localisation, interacts genetically with parkin []. It is highly expressed in larval neuroblasts, affects mitochondrial localisation and suppresses mitochondrial oxidative damage [].Budding yeast Clu1 is a subunit of the eukaryotic translation initiation factor3 (eIF3). It can influence mitochondrial morphology and distribution []. Arabidopsis CLU, also known as FRIENDLY (At3g52140), is involved in regulating intermitochondrial association, a prelude to mitochondria fusion [, ]. FRIENDLY may have expanded into a small gene family to help manage the energy metabolism of cells that contain both chloroplasts and mitochondria. These homologue are known as REDUCED CHLOROPLAST COVERAGE (REC) 1/2/3 (AT1G01320 , AT4G28080, AT1G15290). Together, they contribute to establishing the size of the chloroplast compartment []. |
