| First Author | Jones JM | Year | 1992 |
| Journal | Genomics | Volume | 14 |
| Issue | 1 | Pages | 197-9 |
| PubMed ID | 1358794 | Mgi Jnum | J:2158 |
| Mgi Id | MGI:50682 | Doi | 10.1016/s0888-7543(05)80308-8 |
| Citation | Jones JM, et al. (1992) Localization of insulin-2 (Ins-2) and the obesity mutant tubby (tub) to distinct regions of mouse chromosome 7. Genomics 14(1):197-9 |
| abstractText | A DNA mapping panel derived from an interspecific backcross was used to position the mouse insulin-2 locus (Ins-2) on Chromosome 7, near H19 (0/114 recombinants) and Th (1/114 recombinants). Ins-2 is part of a human-mouse conserved linkage group that includes Th, H19, and Igf-2. Analysis of segregation in the F2 generation from the cross C57BL/6J-tub/tub x CAST/Ei demonstrated that Ins-2 and the obesity mutant tubby (tub) are distinct loci, thus eliminating Ins-2 as a candidate gene for tub. These results also refine the estimated genetic distance between tub and Hbb to 2.4 +/- 1.4 cM. The predicted location for a human homolog of tubby is HSA 11p15. |
