|  Help  |  About  |  Contact Us

Publication : Molecular cloning and chromosomal mapping of feline p53 tumor suppressor gene.

First Author  Okuda M Year  1993
Journal  J Vet Med Sci Volume  55
Issue  5 Pages  801-5
PubMed ID  8286534 Mgi Jnum  J:17956
Mgi Id  MGI:65979 Doi  10.1292/jvms.55.801
Citation  Okuda M, et al. (1993) Molecular cloning and chromosomal mapping of feline p53 tumor suppressor gene. J Vet Med Sci 55(5):801-5
abstractText  Alterations of the p53 tumor suppressor gene have been observed in a variety of human and mouse tumors. For investigation of the role of this gene in tumors in cats, feline p53 cDNA was molecularly cloned by PCR amplifications using primers based on the sequences conserved among several species. The cloned cDNA appeared to cover approximately 90% of the open reading frame of the feline p53 gene and had characteristic structures in common with the p53 genes of several other species. The amino acid sequence similarities of the feline p53 with the human, mouse, rat and chicken counterparts were 82.9%, 75.6%, 76.5% and 57.2% respectively. Moreover, using a panel of feline x rodent somatic cell hybrids, the feline p53 gene was assigned to feline chromosome E1. These data will be useful for determining the role of the p53 tumor suppressor gene in feline tumors.
Quick Links:
 
Quick Links:
 

Expression

Publication --> Expression annotations

 

Other

0 Bio Entities

0 Expression