| First Author | Chan R | Year | 2002 |
| Journal | Mol Cell Biol | Volume | 22 |
| Issue | 4 | Pages | 1073-8 |
| PubMed ID | 11809799 | Mgi Jnum | J:74283 |
| Mgi Id | MGI:2158021 | Doi | 10.1128/MCB.22.4.1073-1078.2002 |
| Citation | Chan R, et al. (2002) The Catalytic Activity of the ErbB-2 Receptor Tyrosine Kinase Is Essential for Embryonic Development. Mol Cell Biol 22(4):1073-8 |
| abstractText | Activation of the epidermal growth factor receptor (EGFR) family is thought to play a critical role in both embryogenesis and oncogenesis. The diverse biological activities of the EGFR family are achieved through various ligand-receptor and receptor-receptor interactions. One receptor that has been found to play a central role in this signaling network is ErbB-2/Neu, and it is considered the preferred heterodimerization partner for other members of the EGFR family. To assess the importance of the catalytic activity of ErbB-2 in embryonic development, we have generated mice expressing a kinase-dead erbB-2 cDNA under the transcriptional control of the endogenous promoter. Here, we show that mice homozygous for the kinase-dead erbB-2 allele die at midgestation and display the same spectrum of embryonic defects seen in erbB-2 knockout mutants. These observations suggest that the catalytic activity of ErbB-2 is essential for normal embryonic development. |
