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Protein Coding Gene : Prkcg protein kinase C, gamma

Primary Identifier  MGI:97597 Organism  mouse, laboratory
Chromosome  7 NCBI Gene Number  18752
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable calcium,diacylglycerol-dependent serine/threonine kinase activity and protein serine/threonine/tyrosine kinase activity. Involved in several processes, including modulation of chemical synaptic transmission; negative regulation of protein metabolic process; and response to morphine. Acts upstream of or within chemosensory behavior and regulation of phagocytosis. Located in several cellular components, including dendrite; postsynaptic density; and synaptic membrane. Is active in calyx of Held and presynaptic cytosol. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and hemolymphoid system gland. Used to study spinocerebellar ataxia type 14. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 14. Orthologous to human PRKCG (protein kinase C gamma).
PHENOTYPE: Depending upon genetic background, homozygous null mice show mild deficits in spatial learning and contextual conditioning. Genotype-dependent reductions in sensitivity to the effects of ethanol on righting reflex and hypothermia, in neuropathic pain after injury, and in anxiety are also evident. [provided by MGI curators]
  • synonyms:
  • MGD-MRK-13329,
  • Prkcg,
  • Pkcc,
  • Prkcc,
  • PKCgamma,
  • protein kinase C, gamma

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

0 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

26 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

3 Driver For