| First Author | Horvat S | Year | 1998 |
| Journal | Genomics | Volume | 54 |
| Issue | 1 | Pages | 159-64 |
| PubMed ID | 9806843 | Mgi Jnum | J:51044 |
| Mgi Id | MGI:1314518 | Doi | 10.1006/geno.1998.5540 |
| Citation | Horvat S, et al. (1998) A 500-kb YAC and BAC contig encompassing the high-growth deletion in mouse chromosome 10 and identification of the murine Raidd/Cradd gene in the candidate region. Genomics 54(1):159-64 |
| abstractText | The mouse high growth (hg) gene was identified in a selection experiment for rapid growth. It produces a 30-50% increase in weight gain of homozygous individuals without resulting in obesity. Recently, hg was mapped to a deletion around marker D10Mit69. Here we report a map of yeast artificial chromosome and bacterial artificial chromosome clones spanning the entire region deleted in high-growth mice. The size of the deletion estimated from the clone lengths is approximately 500 kb. Using exon trapping, the murine Raidd/Cradd gene was identified in the hg region, and its cDNA sequence and expression pattern were determined. The human RAIDD/CRADD was mapped using radiation hybrid mapping to human chromosome 12, 2.9 cR distal to marker AFMB311WC5. The identified Raidd/Cradd gene, which is deleted in high-growth mice, presents a potential candidate for hg. Copyright 1998 Academic Press. |
