| First Author | Takahashi H | Year | 1996 |
| Journal | Neurosci Lett | Volume | 206 |
| Issue | 2-3 | Pages | 113-6 |
| PubMed ID | 8710164 | Mgi Jnum | J:36122 |
| Mgi Id | MGI:83483 | Doi | 10.1016/s0304-3940(96)12449-6 |
| Citation | Takahashi H, et al. (1996) Molecular cloning and expression of the rat homologue of presenilin-1. Neurosci Lett 206(2-3):113-6 |
| abstractText | The rat homologue of the presenilin-1 (PS-1) gene, which is responsible for early-onset familial Alzheimer's disease linked to chromosome 14, was cloned and sequenced. The predicted amino acid sequence showed quite high homology among rat, mouse, and human PS-1. Especially, the amino acid sequences of the putative transmembrane domains were highly conserved among the three species. The expression level of the PS-1 gene increased during brain development and the number of transcripts of the PS-1 gene changed during brain development. We found one transcript of the PS-1 gene in embryonic day 12 (E12)-E15 rat brain and two transcripts in E18-adult rat brain. Therefore, PS-1 may play a role in neurogenesis. |
