Primary Identifier | MGI:88327 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 12487 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Enables protein kinase binding activity. Acts upstream of or within several processes, including positive regulation of immune response; positive regulation of macromolecule biosynthetic process; and regulation of lymphocyte activation. Located in external side of plasma membrane and immunological synapse. Human ortholog(s) of this gene implicated in multiple sclerosis and type 1 diabetes mellitus. Orthologous to human CD28 (CD28 molecule). PHENOTYPE: Homozygous mutation of this gene results in impairment of some T cell responses and decreased basal immunoglobulin levels. Mutant animals have reduced T helper cell activity and impaired T cell response to lectins, but cytotoxic T cells can still be induced. [provided by MGI curators] |