| First Author | Chang SH | Year | 2011 |
| Journal | Immunity | Volume | 35 |
| Issue | 4 | Pages | 611-21 |
| PubMed ID | 21982598 | Mgi Jnum | J:177650 |
| Mgi Id | MGI:5295790 | Doi | 10.1016/j.immuni.2011.09.010 |
| Citation | Chang SH, et al. (2011) Interleukin-17C Promotes Th17 Cell Responses and Autoimmune Disease via Interleukin-17 Receptor E. Immunity 35(4):611-21 |
| abstractText | Although several interleukin-17 (IL-17) family members and their receptors have been recently appreciated as important regulators in inflammatory diseases, the function of other IL-17 cytokines and IL-17 receptor-like molecules is unclear. Here we show that an IL-17 cytokine family member, IL-17C, was induced in a Th17 cell-dependent autoimmune disease and was required for its pathogenesis. IL-17C bound to IL-17RE, a member of IL-17 receptor family whose full-length isoform was selectively expressed in Th17 cells and signaled via an IL-17RA-RE receptor complex and the downstream adaptor Act1. IL-17C-IL-17RE induced the expression of a nuclear IkappaB family member, IkappaBzeta, in Th17 cells to potentiate the Th17 cell response. Thus, our work has identified a cytokine-receptor pair with important function in regulating proinflammatory responses. This pathway may be targeted to treat autoimmune diseases. |
