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Protein Domain : Stromal interaction molecule, Orai1-activating region

Primary Identifier  IPR032393 Type  Domain
Short Name  SOAR
description  This domain, also known as SOAR, is the Orai1-activating region of STIM1 (stromal interaction molecule 1). STIM1 is a Ca2+ sensor in the endoplasmic reticulum. As the store of calcium is depleted the calcium sensor in the ER activates Orai1, a Ca2+-release-activated Ca2+ (CRAC) channel, in the plasma membrane. The SOAR region forms a dimer, and is essential for oligomerisation of the whole of STIM1 [].
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22 Protein Domain Regions

Trail: ProteinDomain




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