| First Author | Acloque H | Year | 2011 |
| Journal | Dev Cell | Volume | 21 |
| Issue | 3 | Pages | 546-58 |
| PubMed ID | 21920318 | Mgi Jnum | J:181010 |
| Mgi Id | MGI:5308527 | Doi | 10.1016/j.devcel.2011.07.005 |
| Citation | Acloque H, et al. (2011) Reciprocal repression between Sox3 and snail transcription factors defines embryonic territories at gastrulation. Dev Cell 21(3):546-58 |
| abstractText | In developing amniote embryos, the first epithelial-to-mesenchymal transition (EMT) occurs at gastrulation, when a subset of epiblast cells moves to the primitive streak and undergoes EMT to internalize and generate the mesoderm and the endoderm. We show that in the chick embryo this decision to internalize is mediated by reciprocal transcriptional repression of Snail2 and Sox3 factors. We also show that the relationship between Sox3 and Snail is conserved in the mouse embryo and in human cancer cells. In the embryo, Snail-expressing cells ingress at the primitive streak, whereas Sox3-positive cells, which are unable to ingress, ensure the formation of ectodermal derivatives. Thus, the subdivision of the early embryo into the two main territories, ectodermal and mesendodermal, is regulated by changes in cell behavior mediated by the antagonistic relationship between Sox3 and Snail transcription factors. |
