| Primary Identifier | MGI:1930970 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Spi1 |
| Inheritance Mode | Recessive | Transmission | Germline |
| Strain of Origin | 129S/SvEv-Gpi1<c> | Is Recombinase | false |
| Is Wild Type | false |
| description | This targeted mutation in the Sfpi1 locus causes death of mutant homozygotes in late gestation. These embryos showed a multilineage defect in generation of progenitors for B and T lymphocytes, for monocytes, and for granulocytes. Megakaryocytes and erythroid progenitor cells were produced in normal numbers, though erythroblast maturation was impaired in some mice. The affected lineages require a function acting at the level of a common progenitor cell (J:20348); perhaps the induction of colony stimulating factor genes may represent at least part of the effect. |
| molecularNote | Replacement of a portion of exon 5, including sequences encoding amino acids 200-272, with a neomycin cassette. |
