| Primary Identifier | MGI:98865 | Organism | mouse, laboratory |
| Chromosome | 18 | NCBI Gene Number | 22139 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable identical protein binding activity and thyroid hormone binding activity. Predicted to be involved in purine nucleobase metabolic process. Predicted to be located in extracellular region. Predicted to be part of protein-containing complex. Predicted to be active in extracellular space. Is expressed in several structures, including brain; egg cylinder; gut; reproductive system; and urinary system. Used to study transthyretin amyloidosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyloidosis; carpal tunnel syndrome 1; dystransthyretinemic hyperthyroxinemia; and transthyretin amyloidosis. Orthologous to human TTR (transthyretin). PHENOTYPE: Homozygous mutation of this gene results in decreased circulating thyroxine, triiodothyronine, and retinol levels. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
