Primary Identifier | MGI:4438612 | Allele Type | Targeted |
Attribute String | Hypomorph | Gene | Slc20a1 |
Transmission | Germline | Strain of Origin | 129S2/SvPas |
Is Recombinase | false | Is Wild Type | false |
molecularNote | An FRT flanked neo cassette was inserted in intron 5 and exon 5 was flanked 5' and 3' with loxP sites 532 bp upstream and 934 bp downstream. Aberrant splicing due to the use of cryptic splice sites results in a hybrid mRNA containing an additional portion of intron 5 and the coding sequence of neo. Wild-type RNA is reduced in this hypomorphic allele. |